Also: it makes no bloody sense
rather they exhibit significant cross-talk ( Complement activation by smoking: possible suspects Concerning the potential tobacco chemicals that might activate the complement system, while the data available thus far are limited, activation of the classical pathway by tobacco glycoprotein (TGP)- which is derived from tobacco leaves- and a similar substance from cigarette smoke condensate- referred to as TGP-S- was explored ( Smoldering tobacco products produce particulate matter (PM), which is a major indoor air pollutant that has been linked to multiple diseases, including cancer ( C 3 - / - ) mice ( ex vivo and in vivo through the rise in both C3a and C5a, which was found to be mainly mediated by fine particulate matter PM 2.5 ( Tobacco smoking was also linked to a profile of toxic metals such as arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), and lead (Pb) ( As was highlighted earlier in this review, tobacco smoking is linked/contains a host of different chemicals, some of which are known to be highly toxic ( Figure 2 )
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