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Limitations and future improvements of the study Future studies should check for more direct measurement of NADPH oxidase activation in endothelial cells that may complement the oxidative burst measurements in macrophages

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nAChR: neuronal nicotinic acetylcholine receptor

Combined hormonal birth control may also increase the risk of CVD

A major contributor to this rise in spending is likely due to the effects of a higher prevalence of cigarette smoking among people who were newly insured under the Patient Protection and Affordable Care Act from 2010-2014 and their subsequent increased use of medical services