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Evidence of significant differences observed in the degree of site-specific methylation in each of the 22 autosomes as a function of tobacco smoking ( KLF6, STK32A, TERT, MSH5, ACTA2, GATA3, VTI1A , and CHRNA5 ( Bioinformatics Applications in Tobacco Smoke-Associated Cancer Genes There are several definitions of Bioinformatics, in this article we use NIH working definition of bioinformatics Research, development, or application of computational tools and approaches for expanding the use of biological, medical, behavioral or health data, including those to acquire, store, organize, archive, analyze, or visualize such data. The U.S