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In the case where more than 10% of subject observations for the whole study population exhibit positive pre-dose concentrations higher than 5% of their respective C max (irrespective of the product received), observed nicotine concentrations were adjusted for baseline nicotine (baseline-adjusted) for all subjects including those subjects whose positive pre-dose concentrations are lower than 5% of their respective C max (irrespective of the product received)

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Bullwinkle said his group supports regulation that would allow manufacturers to sell flavored products if they can demonstrate that flavors help adults quit smoking, do not encourage consumption among young people and are not toxic to consumers