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Similar to the effects seen by overexpression of MnSOD in the mitochondria, mtDNA induced lung inflammation was enhanced in mice with a deleted aconitase-2 (ACO-2) gene ( 2 by the mitochondria, leading to oxidation and inactivation of the ACO-2 substrate, and hence further accumulation of citrate to promote increased mtDNA synthesis

DOI:10.1093/aje/154.12.1119 37

And its damn hard to quit

He still recalls that quarter acre yielding him 375 pounds of tobacco after that summer in 1963