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The parent drug is detectable for only a few hours, typically 4 to 8, and may remain up to about 24 hours, because the liver rapidly converts ketamine to norketamine

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These findings underscore the pivotal role of the gut microbiome not only in intestinal health but also in the pathogenesis of a broad spectrum of systemic diseases, highlighting its potential as both a therapeutic target and a biomarker for disease detection

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