One cross-sectional case-control study showed that compared with nonvaping control subjects, regular ENDS users had a shift in autonomic balance toward sympathetic predominance, higher low-density lipoprotein oxidation, and elevated markers of inflammation, suggestive of an association with increased cardiovascular risk
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This concept of pathergy may explain why low-grade heat exposure from holding the vaping device, as well as toxic substances, may also be implicated in the pathophysiology of SS
