Some of these aldehydes such as 4-hydroxynonenal, 4-hydroxyhexenal, and malonaldehyde are highly reactive and may be considered as second toxic messengers which will cause the cross-linking polymerization of life macromolecules such as proteins and nucleic acids, and affect the activities of mitochondrial respiratory chain complexes and key enzymes in mitochondria, resulting in cell death (Figure 3)
(Bayl Univ
Potential Side Effects and Safety Concerns Although the treatment is safe in medically supervised settings, mild side effects can happen, such as: Temporary redness or swelling at the injection site Slight dizziness or nausea Rare allergic reactions (rash, itching) Patients are advised to disclose any history of allergies or chronic illness before starting treatment
Does anyone know if there's a mechanism by which this happens, or has anyone else experienced the same
An analysis of data from 596 PsA patients in the British Society for Rheumatology Biologics Register (BSRBR) found that the safety profile with these agents was not substantially different from that with nonbiologic DMARDs, and that the safety in PsA patients was similar to that seen in serologically negative RA patients
