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Environmental levels and human exposure 1.1.5

Under oxidative stress, the transcription factor Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2) translocates from the cytoplasm into the nucleus and binds to the antioxidant response element (ARE)

Its small molecular size enables direct action at the intestinal epithelium

In both the intestinal epithelium and liver, they are rapidly transformed into hydrophilic metabolites through phase II enzymatic reactions such as glucuronidation, sulfation, and methylation, catalyzed by enzymes including uridine 5-diphospho-glucuronosyltransferase, sulfotransferase, and catechol- O -methyltransferase

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