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Many patients experience: Delayed gastric emptying Severe nausea Bloating Early satiety Semaglutides mechanism includes: Slowing gastric emptying Reducing GI motility Increasing satiety via vagal pathways Clinical observations also increasingly report: Worsening nausea Increased bloating Vomiting Gastroparesis-like symptoms So, while potentially beneficial in metabolic disease or overweight patients, in individuals already predisposed to gastrointestinal dysmotility, autonomic dysfunction, and vagal dysregulation, these effects can be extremely problematic and counterproductive

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However, it is noteworthy that 20% of patients treated with the 2.4 mg dose of pemvidutide discontinued treatment due to adverse events, with nausea and vomiting being the most common AEs

Finimundy et al., 2013)