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Building on these tools, new dual agonist fluorescent probes such as daLUXendins enable the simultaneous investigation of GLP1R and GIPR (glucose-dependent insulinotropic polypeptide receptor), a critical advancement for studies on multi-agonist therapeutics in diabetes and obesity

doi: 10.1111/dom.13343

GLP-1 has a variety of effects, originating from the presence of its receptors in specific nuclei of the lung, pancreas, gastrointestinal tract, kidney, heart, bone, central nervous system, etc

doi: 10.1016/s1367-5931(98)80033-1

GLP-1R mediated effects on visceral illness Much debate exists around whether the suppression of feeding induced by GLP-1 and GLP-1 mimetics is solely a homeostatic effect