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doi: 10.3748/wjg.v16.i23.2851

Pathogenesis of Alzheimer's Disease The pathogenesis of AD is multifactorial, involving the interplay of genetic, environmental, amyloidbeta (A) plaque deposition, tau hyperphosphorylation, oxidative stress, neuroinflammation, and synaptic dysfunction

Importantly, directly comparing the single KO phenotype across four conditions highlighted 19 nutrient-dependent phenotypes that are otherwise mild in any single condition, which we termed GxE interactions (Fig

Glutathione, usually termed the master antioxidant, is naturally found in every cell of the human body

Here, its cofactor is oxidised by one molecule of hydrogen peroxide and then regenerated by transferring the bound oxygen to a second molecule of substrate