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Before loading into dialysis bags, nanoparticle suspensions containing 10 mg LC were centrifuged at 14,000 rpm for 30 min and resuspended in 2 mL PBS

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Hart AM, Wilson AD, Montovani C, et al

Overexpression of IRP2 or MPP + treatment significantly enhances the binding of IRP2 to p53 in PC-12 cells, upregulates p53 levels, downregulates SLC7A11 expression, and increases arachidonate 12-Lipoxygenase (ALOX12) expression, thereby promoting ferroptosis and amino acid antioxidant system disruptions, elevating MDA levels, and inducing PC-12 cell damage

semaglutide was approved for marketing in the United States in September 2017 66