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In CKD, uremic toxins (e.g., indoxyl sulfate) synergize with iron overload to suppress GPX4, further enhancing ROS-mediated eryptosis ( 4 The role of eryptosis in patients 4.1 The role of eryptosis in non-dialysis-dependent patients Eryptosis, the programmed death of erythrocytes characterized by PS exposure on the cell membrane, has emerged as a critical contributor to renal anemia in non-dialysis-dependent chronic kidney disease (NDD-CKD), with estimated glomerular filtration rate (eGFR) identified as its key determinant ( r 2 = 0.22) and the NDD-CKD subgroup ( r 2 = 0.10)
Avoid self-prescribing high doses, mixing multiple antioxidant supplements without guidance, and skipping medical consultation
[DOI] [PMC free article] [PubMed] [Google Scholar] 751.Rosenberg SA, Restifo NP
EVs play a critical role in intercellular communication by transporting bioactive proteins, lipids, and RNAs, making them a valuable source of circulating biomarkers for various diseases [49, 51,52,53]
Plates were maintained during 710 days at 37 C, 5 % CO 2
