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In the environment of mature follicles, oxidative damage can further trigger chronic inflammatory reactions in the ovaries

[9] Wilding, J., Batterham, R., Calanna, S., et al

In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]

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sodium retention results in water retention, and sodium excretion results in water excretion