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However, Snyder added, treating 788 men for one year is far too few to draw conclusions about the clinical significance of the increase in coronary artery plaque volume and the cardiovascular risk of testosterone treatment. Testosterone may increase risk of heart attack and stroke by promoting vascular calcification

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Women Clinical trials have generally shown similar efficacy across sexes, though some differences emerge: Men: Typically higher absolute weight loss (due to higher starting weights) May tolerate higher doses with fewer GI side effects Greater lean mass preservation during weight loss Similar percentage body weight reductions to women Women: Higher reported incidence of nausea (possibly due to reporting differences) May require more gradual titration Similar metabolic benefits at equivalent doses Contraindicated during pregnancy and breastfeeding Questions about " what is cagrilintide for men " often relate to these subtle differences in response patterns, though the fundamental mechanisms and dosing approaches remain consistent across sexes

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