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For a while, it seemed like promising biology without a path forward

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4.4.3 Immunosuppressive therapy 4.4.3.1 Calcineurin inhibitors Calcineurin inhibitors (CNIs), such as cyclosporine A and tacrolimus, mitigate immune-mediated renal injury in DKD by suppressing T cell activation through the blockade of nuclear factor of activated T cells (NFAT) signaling