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Williams reported that while central blockade of the GLP-1 system with ICV administration of exendin 939 blocked the actions of central but not peripheral GLP-1, peripheral (intraperitoneal) exendin 939 blocked the appetite-suppressing actions of peripheral, but not central GLP-1, indicating that the two systems do not depend on each other for activity

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Research from the Ohio State University also shows that meal timing and eating habits help to activate GLP-1 naturally

Realistic Expectations: Weight Loss Results Without Exercise on GLP-1 How fast can you lose weight on GLP-1 without exercising

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