"For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM , that explain poor responders to their medications." "There are a whole class of medications that are insulin sensitizers, so perhaps we can develop medications that will allow people to be sensitized to GLP-1s or find formulations of GLP-1, like the longer-acting versions, that avoid the GLP-1 resistance." The research has been published in Genome Medicine .
In a meta-analysis of 8 trials with 59,747 patients there was a robust decrease in the composite end points of renal disease (HR 0.62
Pfaus, J
[96] Due to the absence of amino acids such as methionine, cysteine, and glutamine, ALW is physiologically stable and is resistant to peptide oxidation, cyclization, and degradation
Exploratory pilots are giving way to enterprise-scale deployments with vendors that can prove production readiness