Agmatine co-transmission in addiction Given reports of Glu/Agm co-transmission, and Agms dual roles as an extracellular antagonist of NMDA receptors (Figure 2) and an intracellular antagonist of NOS, it is reasonable to hypothesize that Agm may interact with the NMDA-NOS axis involved in addiction-driven learning experienced during withdrawal (Uzbay, 2012)
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It works through a completely different mechanism (amylin pathway) which provides paired effects when combined with GLP-1 agonists
However, the research has all been in labs or on animals, making the results difficult to generalize to humans
