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C-peptide parameters, such as fasting levels, peak and nadir, were comparable between the groups ( p = 0.291, p = 0.272 and p = 0.062, respectively, Table 2)

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In these patients, mixed agonist/antagonist and partial agonist analgesics may reduce the analgesic effect and/or precipitate withdrawal symptoms (see PRECAUTIONS, Drug Interactions)

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