However, this conclusion is limited in practice by several important consideration: a) MDA yield as a result of lipid peroxidation varies with the nature of the PUFA peroxidised (specially its degree of instauration) and the peroxidation stimulus, b) only certain lipid oxidation products decompose yield MDA, c) MDA is only one of several end product of fatty peroxide formation and decomposition, d) the peroxidation environment influences both the formation of lipid-derived precursors and their decomposition to MDA, e) MDA itself is a reactive substance which can be oxidative and metabolically degraded, f) oxidative injury to no lipid biomolecules has the potential to generate MDA
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