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Kiyoshi Matsumoto and Takahiro Yoshizawa (Research Center for Support to Advanced Science, Shinshu University) for technical assistance and care of mice

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MS experimental conditions included an ESI voltage of 3 kV, sheath gas flow rate of 50 (arbitrary units), aux gas flow rate of 5, sweep gas flow rate of 1, capillary temperature of 320 C, S-Lens RF level of 50, and aux gas heater temperature of 350 C, with both positive and negative mode acquisition