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While Novo Nordisk may be glum about the upcoming patent expirations, the moment is one that generic-drug companies and peptide producers across India, China, and Europe have been rehearsing long and hard for, as they will be able to sell copycat versions of semaglutide

Molecules 26:4571

The clinical data in this regard is still very limited and needs expanding through randomized, placebo-controlled studies to draw final conclusions on whether polyphenols may be a class of clinically effective nutraceuticals in patients with CFS

[76] [77] In a 72-week, phase IIIb open-label head-to-head trial of adults with obesity without diabetes, tirzepatide at the maximum tolerated dose produced greater mean weight loss than semaglutide and larger reductions in waist circumference, while gastrointestinal adverse events were the most common with both drugs