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Studies from the Saint Petersburg group suggest that bioregulatory peptides targeting cartilage may influence the balance between matrix synthesis and degradation by modulating expression of both structural proteins and matrix-degrading enzymes

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Serum samples from patients with RA, primary Sjgrens syndrome, and HC were analyzed using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry

Nevertheless, ADA 2023 suggests that metformin's benefits on MACE remain potential and dubious [9], indicating that for patients with high risk of MACE, metformin combined with SGLT-2i or GLP-1 RAs with proven cardiovascular benefits may still contribute to the decrease of MACE risk