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GLP-1s In the Lean mass loss on GLP-1 receptor agonists: a downside of the miracle drugs Peter Attia states , [t]hough a certain amount of lean loss is inevitable with significant weight reduction (usually about 25% of total weight loss), the goal is to increase the bodys overall proportion of lean mass in other words, to improve body composition While the data so far are limited, the data in the STEP 1 trial for semaglutide show that lean muscle mass accounted for ~39% of the weight loss, which is undoubtedly higher than ideal

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Brant WO, Bella AJ, Garcia MM, Tantiwongse K, Dean RC, Lue TF