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Consistent reduction in major cardiovascular events, even beyond glycaemic effects Meaningful kidney protection, slower eGFR decline & reduced albuminuria Benefits across phenotypes: diabetes, obesity, HFpEF, CKD & ASCVD A clear shift from organ-specific treatment to system-level risk reduction The next phase feels less about whether these agents work & more about who benefits most, when to start & how to integrate them alongside SGLT2 inhibitors and standard CV therapies

Drug Interactions: Inform your doctor about other medications, especially if taking anticonvulsants, antibiotics, or anticoagulants

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Metformin is a safe and highly effective drug treatment for T2D and is the most commonly prescribed drug to treat the disorder