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Omics platforms, including single-cell level analyses such as single-cell RNA sequencing (scRNA-seq), provide deep insights into -cell heterogeneity, revealing distinct functional subpopulations that differ in maturity, metabolic activity, and susceptibility to external stressors such as inflammation, glucotoxicity, and the endoplasmic reticulum (ER) stress they mediate

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It has been proven that the accumulation of senescent cells is responsible for tissue aging, and it has been observed that the pace of this process increases with age [100]