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Among them, retatrutide has shown significant clinical advantages in phase II clinical trials, reducing the weight of obese patients by up to 24.2% in 48 weeks and lowering the HbA1c of type 2 diabetes patients by 2.2% in 36 weeks (49, 50)

Lipid peroxy radicals mediated tyrosine dimerization and nitration in membranes

Molecules , 19, 19066 19077

4.3 The vicious cycle of metabolic deficits and immune activation Mitochondrial dysfunction may result in overproduction of ROS and the release of mtDNA, both of which serve as DAMPs, activating the NLRP3 inflammasome in both peripheral and central immune systems, thereby promoting the release of pro-inflammatory cytokines, such as IL-1 and IL-18 (168170)