Additionally, the administration of safflower extract, which comprises both HSYA and safflower yellow (also known as carthamine yellow), elevates the mRNA levels of antioxidative enzymes and enhances the superoxide dismutase (SOD) activity in liver homogenates ( The elevation of heart function enzyme activity (troponin and CK) in the hypercholesterolemic positive control group is corroborated by histological analyses that indicated damaged cardiac tissues and oxidative stress markers ( The current findings indicated a notable reduction in vitamin D and calcium levels due to induced hypercholesterolemia in the positive control group, while treatment with safflower and atorvastatin resulted in an elevation of these levels
Figure 4 ALC attenuated atherosclerosis in LDLR / mice To investigate whether ALC influences atherosclerotic progression, we analyzed aortic root sections from mice using H&E and oil red O staining
GLP-1 may modulate lipid metabolism through increased sympathetic tone, leading to increased lipolysis, heightened triglyceride catabolism, and enhanced fatty acid oxidation (181)
Overcoming the shortcomings of peptide-based therapeutics
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