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Nachef M, Ali AK, Almutairi SM, Lee SH

Its appeal to formulators is that it is slightly more soluble and pH-stable in certain vehicle systems compared to GHK-Cu, and it commands a different patent space

The compound incorporates three non-standard structural features: an -aminoisobutyric acid (Aib) at the N-terminus bearing no stereocenter, a D-2-naphthylalanine (D-2-Nal) at position 3, and a D-phenylalanine at position 4

doi: 10.1159/000371851 53 CoronaGMannucciEJanniniEALottiFRiccaVMonamiMet al

Generally, this is essential to purify rHGH depending on their molecular size, net charge, binding affinity, and hydrophobicity