Iron chelators, including Deferoxamine (DFO) and antioxidant molecules, such as errostatins, liproxstatin-1, and vitamin E, are also inhibited pharmacologically
also called glycerine or glycerin
The problem arises when this antioxidant defense is overwhelmed or depleted: *Excess HO damages thyroid follicular cells, triggering inflammation and immune activation *Oxidized thyroid proteins become neoantigens - foreign-looking molecules that the immune system attacks, initiating or amplifying autoimmune thyroid disease *Lipid peroxidation in thyroid cell membranes disrupts hormone synthesis and cellular integrity *Chronic oxidative stress accelerates thyroid cell apoptosis and fibrosis - the hallmarks of Hashimoto's progression A landmark review published in Antioxidants (MDPI, 2021) - "The Influence of Oxidative Stress on Thyroid Diseases" - confirmed that decreased glutathione levels appear to be a distinctive parameter related to the activation and development of oxidative stress in Hashimoto's thyroiditis, and that antioxidant interventions represent a promising therapeutic avenue for autoimmune thyroid conditions
However, both iron excess and deficiency can adversely impact cardiovascular health (26)
Il stabilise les membranes cellulaires et limite les dommages causs par le stress oxydatif li la pollution, au tabac ou linflammation
