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Supporting information Acknowledgements The authors have nothing to report

EMPA-KIDNEY, Study of Heart and Kidney Protection with Empagliflozin

E1 is a TPP-dependent -ketoacid dehydrogenase, E2 is a dihydrolipoamide transacetylase that binds one or two lipoyl groups via covalent amide linkages to lysine residues, and E3 is an FAD-containing dihydrolipoamide dehydrogenase that re-oxidizes dihydrolipoamide using NAD +

This focus led to significant breakthroughs, but it became clear in animal models that single-pathway stimulation had a ceiling effect regarding metabolic stabilization and lipid management

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