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Extracellular Matrix (ECM) Synthesis: The copper ion is a vital cofactor for lysyl oxidase, an enzyme required for the structural cross-linking of collagen and elastin

Hence, an active glucose metabolism partly amplifies the substrate pool for lipid peroxidation ( 3.4.3 Energy status and oxidative stress balance In OA lesions, synovial inflammation and cartilage degeneration reduce local nutrient availability and oxygen levels, compelling cells to adapt their energy-generating modes ( In OA, cells and tissues undergo extensive metabolic reprogramming in response to chronic inflammation and mechanical stress

10.3389/fphar.2014.00023 23 ChungK