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however, in inflammatory disease states, particularly when intestinal barrier integrity and function may be compromised, LPS can enter the circulation, where it can activate TLR4 on inflammatory cells and trigger a systemic inflammatory response

This finding reinforces the concept that visceral and subcutaneous adipose tissues contribute differently to systemic inflammation, and that metabolic control plays a distinct role in disease pathophysiology (105, 106)

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Additionally, most supplement ingredients face bioavailability challenges

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