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10.1038/s41386-018-0010-3 [DOI] [PMC free article] [PubMed] [Google Scholar] Hernandez, N

30 So far, the studies show a mixed effect on cholesterol, with one study showing a small increase in total cholesterol and another study producing a decrease in HDL cholesterol

Vyleesi Label Protocol (FDA-approved) Parameter Dose Value 1.75 mg Source Vyleesi label / Mayo Clinic drug summary Parameter Route Value Subcutaneous (abdomen or thigh) Source Vyleesi label Parameter Timing Value 45 minutes before sexual activity Source Vyleesi label Parameter Maximum frequency Value 1 dose per 24 hours Source Vyleesi label Parameter Maximum monthly use Value 8 doses per month Source Vyleesi label Parameter Approved population Value Premenopausal women with HSDD Source Vyleesi label Reflects the FDA-approved Vyleesi label as summarized by Mayo Clinic (last updated Feb 2026)

If you have anemia (a condition where your blood doesnt have enough healthy red blood cells), B-12 injections could help fix the issue, Stanford says

Even with approval, authorization periods typically last 12 months and may require annual reapplication