The antioxidant activity is especially critical for the operation of glutathione peroxidase (GPx), an enzyme that catalyzes the reduction of peroxides using GSH as an electron donor, oxidizing it to its disulfide form, GSSG (glutathione disulfide)
however, paradoxically, these compensatory mechanisms may contribute to HACE pathogenesis ( 3 Progress in research on TCM-based treatment of HACE 3.1 Understanding of HACE in TCM TCM is guided by a holistic view that considers human health dependent on the dynamic coordination between the internal and external environments
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Truhlar, The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four M06-class functionals and 12 other functionals