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meningitidis activates both canonical and non-canonical pathways in the host, with predominance of the alternative caspase-3 mediated-GSDME activation in vitro in different cell lines (Tal et al., 2022) and of the GSDMD-dependent pathway in vivo in an intracisternal infected mouse model of meningitis (Pagliuca et al., 2024)

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This active form functions as an antioxidant by combating free radicals, detoxifying harmful substances, and promoting healthy skin and tissue regeneration

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