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Wang R, Lagakos SW, Ware JH, Hunter DJ, Drazen JM

GEP12 was designed to incorporate findings published by Jones, Buenaventura et al

Unlike acute effects that fade with each injection, skin changes may be persistent or permanent

In the foundational Novo Nordisk pharmacology studies, ipamorelin failed to elevate ACTH or cortisol at doses more than 200-fold above its ED50 for GH release a specificity profile that had not previously been achieved with any GHRP receptor agonist and that fundamentally changed the landscape of GH secretagogue research