Salaiza-Suazo et al, 2024
As integral components of the NVU, perivascular astrocytes maintain BBB characteristics by contributing to basement membrane formation, regulating pericyte differentiation, and modulating EC functions by regulating the expression of TJs such as claudin-5, occludin, and ZO-1 [49, 51,52,53]
The GLP-1 medications currently available to Calibrate members include Mounjaro, Wegovy, Ozempic, Rybelsus, Saxenda, and Trulicity
Taken together, preclinical and clinical studies in neuroblastoma suggest the potential for BSO to enhance L-PAM activity against diseases that use myeloablative dosing of L-PAM and previous investigations with one murine plasmacytoma, 17 and a human MM cell line, 8, 10 demonstrated enhanced activity of L-PAM by BSO
This feasibility study seeks to assess the real-world application of advance consent for participation in acute stroke trials at a comprehensive stroke centre in Canada