The weight loss mechanism differs as well: GLP-1 agonists work through delayed gastric emptying and central appetite suppression, while berberine's weight effects, when present, likely relate to improved insulin sensitivity and metabolic efficiency
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Regarding the safety of LC supplementation, Singh and Aslam [12] indicated that there are some side effects, such as mild nausea and vomiting after LC supplement at a dose of 2000 mg/d, but in three divided doses, supplementation might not cause any side effects
Moreover, also a by-product of ethanol metabolism such as acetaldehyde, which is further oxidised to acetate by mitochondrial aldehyde dehydrogenase, seems to contribute primarily to the alcohol-induced liver diseases by acting at the genomic level through up-regulation of some redox-sensitive transcription factors involved in fibrogen-esis, such as AP-1 and NF-B
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