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GLP-1 agonists are eliminated through the kidneys, making them suitable for patients with mild renal or hepatic impairment without the need for dose adjustments

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For special casessuch as in patients after bariatric surgery or with large hiatal herniasthe classic techniques remain relevant

The mechanism of action of GLP-1 agonists involves binding to GLP-1 receptors on pancreatic beta cells, which stimulates glucose-dependent insulin secretion