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Finally, the survival fraction after RT, either alone or in combination with LDHB silencing, was rescued by the supplementation with mitoTEMPO revealing that not only LDHB silencing but also RT induces mitochondrial lipid peroxidation (Fig

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Current Data Still Favors Bariatric Surgery for Severe Obesity Present evidence indicates: Bariatric surgery provides greater total weight loss Surgery offers superior diabetes remission Surgical outcomes remain more durable Obesity medications are highly effective but require continuation Real-world medication adherence remains challenging However, obesity medications have unquestionably transformed obesity care by: Increasing awareness Reducing stigma Encouraging earlier treatment Expanding therapeutic options This represents a historic advancement in metabolic medicine