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Davies, U
During oxidative stress, the level of GSH/GSSG ratio falls, which is a marker of cellular injury
Biliary Copper Excretion Bile is the major physiologic route for eliminating excess copper
Further studies revealed that DAA was able to bind to Keap1 in the cytoplasm and increase the luciferase activity of Nrf2-antioxidant reactive element (ARE), promoting the expression of downstream antioxidant gene hame oxygenase-1 (HO-1), GSH, and GPx4 through the Keap1/Nrf2 pathway, while DAA treatment results in achieving attenuation of ROS and lipid peroxidation (36)
This normalization can result in improved sleep quality, mood stabilization, and enhanced cognitive function Anisimov et al., Neuroendocrinol Lett , 2001
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