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Group size is the number of independent values, and data displaying a normal distribution was expressed as mean SEM based on at least three independent experiments and analyzed by GraphPad Prism 9.0 (GraphPad Software, San Diego, CA)

Found in foods like whole grains, nuts, and seeds, fruits and vegetables which may have a mix of soluble and insoluble fiber

Metabolic unpredictability: Simultaneously altering multiple metabolic pathways incretin signalling, glucagon activity, and NAD+ metabolism without clinical oversight introduces unpredictable physiological consequences

Research programmes exploring energy expenditure mechanisms, hepatic lipid metabolism, or multi-receptor metabolic modelling require a triple-axis compound that tirzepatide cannot provide

Instead, the medication typically reduces blood pressure through weight loss and improved metabolic function