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In 2015, AMD affected approximately 67 million individuals in Europe, with projections indicating an increase to 77 million by 2050 [409]

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A risk study of ASD with typical development indicated significant interaction effects between maternal TT genotype and greater risk for ASD 82 , suggesting MTHFR polymorphism might involve the early development of ASD

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Its primary mechanism involves activating hepatocyte growth factor (HGF) and c-Met signaling, which plays crucial roles in neuronal growth and synaptic formation