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In the absence of SIRT4, a failure to undergo cell cycle arrest induced by DNA damage causes a delay in DNA repair and increased chromosomal instability, suggesting a tumor suppressor effect of SIRT4 151

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These mPTP changes result in more ROS formation, known as ROS-induced ROS release (RIRR), and cause an oxidative stress response (6)

That relationship does not change the conclusion below

In our study, we attempted to explain the effects of acute ethanol intoxication in occasional drinkers on antioxidant salivary proteins