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This suggests that Sirts could be promising therapeutic targets for PD ( 2A receptor by serotonin upregulates mitochondrial biogenesis and ATP production in cortical neurons via Sirt1 and PGC-1 ( Interestingly, similar Sirts dysregulation is observed in diabetes, where reduced Sirt1 and Sirt3 activity compromises mitochondrial function and insulin signaling via the PI3K-Akt-FoxO axis, suggesting a shared molecular mechanism linking metabolic dysfunction and neurodegeneration ( 5 Type 2 diabetes and the role of insulin signaling in PD Type 2 diabetes (T2DM) and PD are both age-associated diseases that have a high prevalence due to increased life expectancy

This injectable triple receptor agonist targets GLP-1, GIP, and glucagon

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