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As a consequence, a loss of lipoic acid-dependent enzymatic activity caused by defects in endogenous lipoic acid synthesis (see Deficiency) cannot be rescued by the provision of exogenous lipoic acid (5)

A major enzyme of steroid hormone metabolism that utilizes NADPH is the ER-localized 11-hydroxysteroid dehydrogenase 1 (11-HSD1) which is encoded by the HSD11B1 gene

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Simultaneous occurrence of cytokine storm and immune suppression during SARS-CoV-2 infection may lead to reactivation of latent HHV in the body