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Given the metabolic and inflammatory components of lipedema, medications that address these pathways have generated clinical interest, including newer incretin-based therapies originally developed for type 2 diabetes and obesity management

Placed on a 'starvation diet' which doctors commonly used in an attempt to help diabetes, in 1922 Thompson was admitted to Toronto General Hospital weighing just 65 pounds and was seriously ill

That said, most weight-focused protocols follow a similar shape: Starting dose: 25 mg to 50 mg daily, usually at night Titration: increased every 1 to 2 weeks depending on tolerance Typical maintenance range: 100 mg to 200 mg per day, where most of the research-backed weight loss shows up Upper limit: around 200 mg for weight management

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(5.6) Hypersensitivity: Serious hypersensitivity reactions (e.g., anaphylaxis and angioedema) have been reported